Post Second Covid Wave, South India May Witness Severe MIS-C Wave in Children: Warn Doctors

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~ Multisystem Inflammatory Syndrome (MIS-C) is an immune system mediated hyper inflammation targeting children, adolescents & young adults; more than 50% develop heart problems ~

July 6, 2021: Doctors at Amrita Hospital are warning of an impending wave of Multisystem Inflammatory Syndrome or MIS-C across South India which may hit children in a big way. They have already begun to see increasing numbers of children coming to the Hospital with MIS-C symptoms and they believe that this is only the beginning. The disease, which mainly affects children who are exposed to Covid positive individuals in their household or themselves have been infected with Covid, begins to manifest symptoms 3-6 weeks after a wave of Covid has already swept through the adult population.

With the second wave of Covid now coming to an end, doctors at Amrita Hospital feel that it is only a matter of time before MIS-C wave will begin to take over the young population. The disease is an immune system mediated hyper inflammation that seems to target children, adolescents, and young adults; more than 50% of those suffering from MIS-C develop heart problems. The severity of heart damage in patients is what determines the outcome of the illness. 

Commenting on the rising incidence of cases, Dr. Suma Balan, Rheumatology AIMS Kochi, said, “MIS-C has been observed to have a correlation with the Covid wave in adults – the larger the Covid wave, the bigger is the MIS-C wave. Since the current Covid wave in South India has been the largest so far, we are anticipating a huge MIS-C wave in Kerala and South India in the months to come. Symptoms of MIS-C include rapidly progressing state of high-grade fever with poor function of several organ systems especially the heart and gastrointestinal organs and are found mostly in Covid negative cases. A child with MIS-C may have been completely asymptomatic if they had COVID-19 infection previously and may not have been tested simply because of lack of symptoms. MIS-C starts to manifest within a period of 4 to 6 weeks of having survived COVID.”

MIS-C needs to be treated by administration of steroids and intravenous immunoglobulin along with supportive management which requires intensive care in most cases. Some children need breathing support and medications to support the failing heart. Because of the high costs of intravenous immunoglobulin, the treatment for MIS-C incurs a high cost.

Elaborating on how MIS-C can affect the heart, Dr Mahesh Kappanayil, Clinical Professor, Department of Pediatric Cardiology, Pediatric CMR Services, said, “It is critical to identify the extent to which the heart is affected by way of ECGs, blood tests and intensive monitoring. In some cases, children may require pacemaker implantation to support heartbeat. The heart shows excellent recovery if supported well during the critical phase of the illness. If the heart is significantly affected, such children need to be given specific medicines to improve heart pumping and to maintain blood pressure, in addition to the overall treatment of MIS-C.”

Explaining the treatment protocols to be followed, Dr Sajith Kesavan, Senior Consultant and Head, Department of Pediatric Pulmonary and Critical Care added, “When MIS-C affected children become sick enough to need intensive care, they also usually need IVIg treatment. Though expensive, this treatment can save a lot of lives. Because of its multisystem presentation, a wide range of medical professionals may need to be consulted by those suffering from it. If a child is suspected to be suffering from MIS-C, it is imperative that a history of a possible Covid link be explored and an appropriate treatment suggested accordingly.”

Dr C. Jayakumar, Head and Professor at the Department of Pediatrics, School of Medicine added “In MISC different systems are involved. But in Kawasaki disease cardiac involvement is the dangerous problem. MIS-C, there is involvement of gastrointestinal tract, lung, kidney, skin in addition. This condition can be fatal if not recognized early and should be managed adequately with not usually used drugs like steroids, intravenous immunoglobulins, immunomodulators and in some cases Extracorporeal membrane support. During this Covid pandemic, irrespective of the fact that one has had Covid or not, if there is fever or other symptoms, medical care must be sought at the earliest. Please do not ignore symptoms of any disease in this season of the pandemic.”

The best ways to tackle MIS-C are through prevention i.e., by ensuring vaccination of all adults in contact with children and management i.e., through timely identification and treatment of the infection. Unless these measures are observed strictly, children will continue to be affected by this deadly disease which may even prove to be fatal if not treated at the earliest.

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“Adoption of AI Inevitable to Achieve Sustainable Development Goals”: Experts

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July 05, 2021: “Connecting Artificial Intelligence (AI), the single biggest technological breakthrough of our times, with Sustainable Development Goals (SDGs) is the only way to ensure that the benefits of technology reach the largest number of people in the largest possible way. The adoption of AI is inevitable for us to achieve necessary progress in the areas of elimination of poverty and hunger, fight climate change, inequality, injustice, and creation of sustainable cities and communities, among other social good targets,” said experts.

Addressing a four-day International Symposium on “Artificial Intelligence for Social Good”, organized by Amrita Vishwa Vidyapeetham, during June 30-July 3, 2021, the experts pointed out that research in the field of AI is on the rise globally. India is no different. In 2020, about 6% of all technology-related patents filed in the country were related to AI. Given the increasing recognition and visibility of AI, it is high time people in the industry and government discussed the potential applications of AI in addressing various social challenges.

About 46 academicians, researchers, and industry experts from nine countries addressed the thematic sessions of the symposium on novel research areas including AI and Accessibility, Agriculture, Autonomous Vehicles, Healthcare and Well-being, Safety & Surveillance and Smart Environments. Over 2,500 people attended this virtual event.  

In his keynote address, Professor Rajat Moona, Director, IIT Bhilai, said, “AI’s potential in the areas of offering personalized and adaptive learning solutions is largely untapped. In addition to helping students learn a subject in multiple ways, AI can also help identify at-risk students in need of counseling. He said that the fear of AI is unwarranted. “AI is here to make our natural intelligence better and our decisions better.” He also pointed out the need for more investment in the areas of data security and data inclusivity. 

Dr. Rajendra Kumar, IAS, Additional Secretary, MeitY, in his address, emphasized the need to align AI applications with the United Nations’ Sustainable Development Goals and to maximize the technology’s positive impact on society. He cited the potential of employing AI in diagnosis of diseases, and surveillance. In education, AI can be used to identify aptitudes of students accurately and help them make better learning and career choices. Dr. Kumar also highlighted India’s growing visibility as a global technology leader. “In a big leap, India has jumped 37 places to be ranked 10th in Global Cybersecurity Index (GCI) 2020,” he pointed out. 

In her address, Dr. Tapati Bandopadhyay, Chair & CEO, AISWITCH Technologies Pvt Ltd, said that in India, AI is now adopted extensively but there are no robust data governance frameworks in place, which is a cause for concern. She emphasized that trust and transparency are the two cornerstones of successful implementation of AI and data tech. She said that in the Indian context, the NITI Aayog is working towards creating a robust data governance framework, which is essential in the increasingly data-driven world. Dr Bandopahdyay expressed concern over the lack of adequate representation of women in AI. “The future of AI is better in girls’ hands,” she said.

Professor Venu Govindaraju, SUNY Distinguished Professor, University at Buffalo, USA, in his address, highlighted the various ways in which AI can be applied for social good. “One of them is to make use of real time data and AI analytics, as opposed to survey results and census data, while addressing poverty eradication. The data ecosystem can include mobile phone data, satellite imagery, weather data, economic data, and AI can help processing heterogeneous data to give different views of poverty, model the uncertainties, and fill in the missing data and come up with ways to combat poverty,” he said.

In her theme address, Professor Prema Nedungadi, Director, AmritaCREATE, Amrita Vishwa Vidyapeetham, said, “AI is certainly the single largest technology revolution in our times. A disruptive technology like AI needs to be seen from the perspective of the transformative impact it can have on the greater social good by improving the quality of life of people and helping them create and access choices.” She said that the areas that require urgent attention include access to quality health facilities, providing real-time advisory to farmers, and building smart and efficient cities and infrastructures to meet the demands of rapidly urbanizing populations. 

She pointed out that Amrita University is a key partner on several AI projects of the Indian government. Among them is the project that aims at enhancing the accessibility of Indian Sign Language across UMANG (Unified Mobile Application for New-Age Governance) a single digital platform for all Indian citizens to access pan India e-Gov services ranging from central to Local Government bodies. As an Institution of Eminence, Amrita has accelerated investments in AI Labs along with focused and interdisciplinary research. 

The international symposium witnessed the participation of research scholars and students in poster presentations and Ph.D. colloquium. The event served as an excellent platform for AI enthusiasts from the industry, academicians, and students to stay up-to-date on the latest research trends. To make the virtual symposium accessible and inclusive, registration was made free and open to all. 

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Bharat Biotech Concludes Final Analysis for COVAXIN® Efficacy from Phase 3 Clinical Trials

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●    Efficacy analysis demonstrates COVAXIN® to be 77.8% effective against symptomatic COVID-19, through evaluation of 130 confirmed cases, with 24 observed in the vaccine group versus 106 in the placebo group

●    Efficacy analysis demonstrates COVAXIN® to be 93.4% effective against severe symptomatic COVID-19

●    Safety analysis demonstrates adverse events reported were similar to placebo, with 12% of subjects experiencing commonly known side effects and less than 0.5% of subjects feeling serious adverse events

●    Efficacy data demonstrates 63.6% protection against asymptomatic COVID-19

●    Efficacy data demonstrates 65.2% protection against the SARS-CoV-2, B.1.617.2 Delta variant 

Hyderabad, July 3, 2021: Bharat Biotech, a global leader in vaccine development and innovation, announced today safety and efficacy analysis data from Phase III clinical trials of COVAXIN®, a whole virion inactivated vaccine against SARS-CoV2, was developed in partnership with ICMR and NIV Pune. 

Phase 3 clinical trials of COVAXIN® was an event driven analysis of 130 symptomatic COVID-19 cases, reported at least two weeks after the 2nd dose, conducted at 25 sites across India. COVAXIN® is formulated with a novel Algel+IMDG adjuvant. IMDG is a TLR7/8 agonist known to induce memory T cell responses along with strong neutralizing antibodies. The activation of cell mediated immune responses is especially valuable in a multi epitope vaccine such as COVAXIN®, where immune protection can be achieved from S, RBD and N proteins alike. IMDG was developed under partnership between Virovax and NIAID, National Institutes of Health USA.

COVAXIN® was well tolerated and the Data Safety Monitoring Board has not reported any safety concerns related to the vaccine.  The overall rate of adverse events observed in COVAXIN® was lower than that seen in otherCovid-19 vaccines. The safety profile of COVAXIN® is now well established based on inactivated vaccines technology, and in large part due to the extensive 20-year safety track record of Bharat Biotech’s vero cell manufacturing platform. Furthermore, Bharat Biotech has so far not sought indemnity for COVAXIN® from the Governments.      

No licensed SARS-CoV-2 vaccine has reported efficacy against asymptomatic infection in a randomised controlled trial, based on qPCR testing. COVAXIN® is the first to report promising efficacy against asymptomatic infections based on qPCR testing that will help in reducing disease transmission. 

Dr. Krishna Ella, Chairman & Managing Director, Bharat Biotech, said, “The successful safety and efficacy readouts of COVAXIN® as a result of conducting the largest ever COVID Vaccines trials in India establishes the ability of India and developing world countries to focus towards innovation and novel product development. We are proud to state that Innovation from India will now be available to protect global populations.” 

COVAXIN® has been specifically designed to meet the needs of global distribution chains, the requirements for which are more critical in low- and middle-income countries.  It has been formulated to enable shipping and long-term storage at 2-8ºC. It is also formulated to adhere to a multi-dose vial policy, thereby reducing open vial wastage, saving money to procurement agencies and governments alike.      

Prof. (Dr) Balram Bhargava, Secretary Department of Health Research & Director General Indian Council of Medical Research, said, “I am delighted to note that COVAXIN®, developed by ICMR and BBIL under an effective public private partnership, has demonstrated an overall efficacy of 77.8% in India’s largest COVID phase 3 clinical trial thus far. Our scientists at ICMR and BBIL have worked tirelessly to deliver a truly effective vaccine of highest international standards. COVAXIN® will not only benefit the Indian citizens but would also immensely contribute to protect the global community against the deadly SARS-CoV-2 virus. I am also pleased to see that COVAXIN® works well against all variant strains of SARS-CoV-2. The successful development of COVAXIN® has consolidated the position of Indian academia and Industry in the global arena.”

Bharat Biotech is a company driven by science and validated by empirical evidence. Its commitment to data transparency has been proven again with 10 publications on COVAXIN®, covering all aspects of product development, all within 12 months.

Bharat Biotech’s commitment to continued improvement of COVAXIN® is well under way with additional clinical trials to establish safety and efficacy in children between 2-18 years of age. A clinical trial to determine the safety and immunogenicity of a booster dose is also in process. Several research activities are being carried out to study variants of concern and to assess their suitability for follow up booster doses.   

Mrs. Suchitra Ella, Joint Managing Director, Bharat Biotech, said, “It is a momentous day for everyone, at Bharat Biotech, as we announce the Final Phase-3 Results of COVAXIN® and its efficacy of 77.8%. We wish to thank ICMR, NIV-Pune, Virovax, DSMB and Adjudication Committee. We earnestly thank our clinical trial sites, Principle Investigators, IQVIA, and every participant who has reposed their faith in COVAXIN®. We SINCERELY thank all our employees for enduring work pressures through the pandemic & lockdowns, with 24×7 commitment amidst unprecedented number of physical challenges, stress and continuous operations. We specially thank our medical affairs team for leading the project, the technical and marketing teams who have relentlessly worked to complete the clinical trials and coordination of 25 sites across the country since May 2020.”

COVAXIN® has been evaluated through neutralizing antibody responses against several variants of concern, namely B.1.617.2 (Delta), B.1.617.1 (Kappa), B.1.1.7 (Alpha), B.1.351 (Beta), P2- B.1.1.28 (Gamma). The data from these studies have been extensively published in peer reviewed journals and available for review in the public domain. 

Prof. (Dr) Priya Abraham, Director National Institute of Virology ICMR said, “The overall efficacy of 77.8 % following the phase III clinical trial of COVAXIN® is wonderful news. ICMR-NIV and BBIL have had very fruitful interactions during this exhilarating journey. Sera from COVAXIN® recipients have also been evaluated against viral variants detected in India i.e., the Alpha, Beta, Zeta, Kappa and Delta. The making of this vaccine entirely on Indian soil is a matter of great pride to every Indian.”

COVAXIN® has now received emergency use authorizations in 16 countries including, Brazil, India, Philippines, Iran, Mexico, etc. with EUA’s in process in 50 countries worldwide. The company is in discussions with WHO to obtain emergency Use Listing for COVAXIN®. The product has been exported to several countries with additional requests for supplies being received.   

Bharat Biotech has established COVAXIN® manufacturing at 4 facilities within India, further expansions are in process to reach an annualized capacity of 1 billion doses by the end of 2021. Technology transfer activities are in progress to companies in United States, and other countries.  

ಶೈಕ್ಷಣಿಕ ಗೊಂದಲಗಳ ನಿವಾರಣೆಗಾಗಿ ರಾಜ್ಯಾದ್ಯಂತ ಆಮ್ ಆದ್ಮ ಪಕ್ಷದಿಂದ ಸಹಿ ಸಂಗ್ರಹಣೆ ಹಾಗೂ ಬೃಹತ್ ಜನಜಾಗೃತಿ ಕಾರ್ಯಕ್ರಮ

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ರಾಜ್ಯದಲ್ಲಿ ತಲೆದೋರಿರುವ ಶೈಕ್ಷಣಿಕ ಶುಲ್ಕಗಳು , ಸರ್ಕಾರಿ ಶಾಲೆಗಳ ದುರ್ವ್ಯವಸ್ಥೆ , ಖಾಸಗಿ ಶಿಕ್ಷಕರ ಸಮಸ್ಯೆ , ಶುಲ್ಕ ನಿಯಂತ್ರಣ ಪ್ರಾಧಿಕಾರದ ರಚನೆ ಸೇರಿದಂತೆ ಹಲವಾರು ಶೈಕ್ಷಣಿಕ ಬೇಡಿಕೆಗಳನ್ನು ಈಡೇರಿಸುವಲ್ಲಿ ಸರ್ಕಾರವು ಸಂಪೂರ್ಣ ವೈಫಲ್ಯಗೊಂಡಿದೆ . ಸರ್ಕಾರದ ಹೊಣೆಗೇಡಿತನದ ಪರಿಣಾಮವಾಗಿ ಇಂದು ರಾಜ್ಯದಲ್ಲಿನ ಸರ್ಕಾರಿ ಹಾಗೂ ಖಾಸಗಿ ಶಿಕ್ಷಣ ವ್ಯವಸ್ಥೆ ಸಾಕಷ್ಟು ಸಂಕಷ್ಟಕ್ಕೀಡಾಗಿದೆ . ಶಾಲಾ ಶುಲ್ಕ ಗಳ ವಿಚಾರದಲ್ಲಿಯೂ ಸಹ ಪೋಷಕ ವರ್ಗ ಸಮಸ್ಯೆಗೀಡಾಗಿದೆ . ಈ ಎಲ್ಲ ಗೊಂದಲಗಳಿಂದಾಗಿ ಲಕ್ಷಾಂತರ ಮಕ್ಕಳು ಶಿಕ್ಷಣ ವಂಚಿತರಾಗುತ್ತಿದ್ದಾರೆ .

ಸರ್ಕಾರದ ಈ ಎಲ್ಲಾ ವೈಫಲ್ಯಗಳನ್ನು ಬಗೆಹರಿಸಲು ಒತ್ತಾಯಿಸುವ ನಿಟ್ಟಿನಲ್ಲಿ ಆಮ್ ಆದ್ಮ ಪಕ್ಷದ ಸಾವಿರಾರು ಕಾರ್ಯಕರ್ತರು ಗಳು ಸತತ 15 ದಿವಸಗಳ ಕಾಲ ರಾಜ್ಯದಾದ್ಯಂತ ಎಲ್ಲ ಜಿಲ್ಲೆ ಹಾಗೂ ತಾಲ್ಲೂಕುಗಳಲ್ಲಿ ಕನಿಷ್ಠ 5 ಲಕ್ಷ ಮನೆಗಳಿಗೆ ತೆರಳಿ ಸಹಿ ಸಂಗ್ರಹಣೆ ಹಾಗೂ ಬೃಹತ್ ಜನಾಂದೋಲನ ಕಾರ್ಯ ಕ್ರಮವನ್ನು ನಡೆಸುವವರಿದ್ದಾರೆ ಎಂದು ಬೆಂಗಳೂರು ನಗರ ಅಧ್ಯಕ್ಷ ಮೋಹನ್ ದಾಸರಿ ಎಂದು ಇಂದಿಲ್ಲಿ ನಡೆದ ಪತ್ರಿಕಾಗೋಷ್ಠಿಯಲ್ಲಿ ಸಮಗ್ರ ಚಿತ್ರಣ ನೀಡಿದರು .

ಕರಪತ್ರ , ಎಲ್.ಇ.ಡಿ ವಾಹನ , ವಿಚಾರಗೋಷ್ಠಿ ಗಳು ಮಾಧ್ಯಮಗಳು ಹಾಗೂ ಸಾಮಾಜಿಕ ಜಾಲತಾಣಗಳ ಮೂಲಕ ಈ ಅಭಿಯಾನವನ್ನು ಯಶಸ್ವಿಯಾಗಿಸಲು ಈಗಾಗಲೇ ಹಲವು ರೂಪುರೇಷೆಗಳನ್ನು ಪಕ್ಷವು ಕೈಗೊಂಡಿದೆ .

ಈ ಬೃಹತ್ ಅಭಿಯಾನದ ಭಾಗವಾಗಿ ಪಕ್ಷದ ರಾಜ್ಯಾಧ್ಯಕ್ಷ ಶ್ರೀ ಪೃಥ್ವಿರೆಡ್ಡಿ ದವರು ದಿನಾಂಕ : 05 – 07 – 2021 ಸೋಮವಾರ ಬೆಳಿಗ್ಗೆ 9 ಗಂಟೆಗೆ ಬೆಂಗಳೂರು ನಗರದ ಸಂಪಂಗಿ ರಾಮನಗರ ವಾರ್ಡ್ ನಲ್ಲಿ ಮನೆ ಮನೆಗೆ ತೆರಳಿ ವಿದ್ಯುಕ್ತವಾಗಿ ಚಾಲನೆ ಯನ್ನು ನೀಡಲಿದ್ದಾರೆ . ಇವರೊಂದಿಗೆ ಬೆಂಗಳೂರು ನಗರ ಅಧ್ಯಕ್ಷ ಮೋಹನ್ ದಾಸರಿ ಪ್ರಚಾರ ಸಮಿತಿ ಅಧ್ಯಕ್ಷ ಶಾಂತಲಾ ದಾಮ್ಲ ಸೇರಿದಂತೆ ಅನೇಕ ಮುಖಂಡರುಗಳು ಹಾಗೂ ಕಾರ್ಯಕರ್ತರುಗಳು ಭಾಗವಹಿಸಲಿದ್ದಾರೆ . ಇದೇ ಸಮಯದಲ್ಲಿ ರಾಜ್ಯದಾದ್ಯಂತ ಎಲ್ಲಾ ಜಿಲ್ಲಾ ಹಾಗೂ ತಾಲ್ಲೂಕು ಕೇಂದ್ರಗಳಲ್ಲಿ ಸಹ ಈ ಅಭಿಯಾನಕ್ಕೆ ಚಾಲನೆ ದೊರಕಲಿದೆ . ಈ ಮೂಲಕ ರಾಜ್ಯದಲ್ಲಿ ತಲೆದೋರಿರುವ ಶೈಕ್ಷಣಿಕ ಸಮಸ್ಯೆಗೆ ಆಮ್ ಆದ್ಮ ಪಕ್ಷವು ರಾಜ್ಯದ ಜನತೆಯ ಧ್ವನಿಯಾಗಿ ಕೆಲಸ ಮಾಡುತ್ತದೆ ಎಂದು ಮೋಹನ್ ದಾಸರಿ ತಿಳಿಸಿದರು .

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